Issue 40, 2024

Polymer coated magnesium hydroxide nanoparticles for enhanced wound healing

Abstract

Wound healing potential is initially evaluated using a chorioallantoic membrane (CAM) assay. Alginate gel containing pristine and polymer-coated magnesium hydroxide nanoparticles (MHNPs) improves the healing response. PEGylated MHNPs have shown a rapid wound-healing process in Gallus gallus domesticus by promoting re-epithelialization as compared to pristine MHNPs. No toxicity or inflammation are observed in the blood, liver, and heart tissues during biochemistry and histopathological examination. Polymer (polyethylene glycol (PEG) and chitosan) functionalized MHNPs are synthesized using a one-step hydrothermal process. The average crystallite size determined from X-ray diffraction analysis of the pristine MHNPs is ∼31.3 nm and upon PEG and chitosan coating it reduces to 23.4 nm and 29.7 nm, respectively. FTIR confirms the presence of functional groups indicating the successful functionalization of the polymers.

Graphical abstract: Polymer coated magnesium hydroxide nanoparticles for enhanced wound healing

Supplementary files

Article information

Article type
Paper
Submitted
25 Apr 2024
Accepted
05 Aug 2024
First published
05 Aug 2024
This article is Open Access
Creative Commons BY license

New J. Chem., 2024,48, 17396-17410

Polymer coated magnesium hydroxide nanoparticles for enhanced wound healing

M. K. Abbas, Y. Javed, N. A. Shad, M. Shahid, B. Akhtar, E. Yasin, S. K. Sharma and N. T. K. Thanh, New J. Chem., 2024, 48, 17396 DOI: 10.1039/D4NJ01909A

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