Issue 26, 2024

Synthesis, structure and biological properties of a series of dicopper(bis-thiosemicarbazone) complexes

Abstract

Fifteen new coordination binuclear compounds of copper(II) were synthesized based on substituted 4-tert-butyl-2,6-bis(N4-thiosemicarbazonyl)phenol (H3L1–3) ditopic ligands. The complexes were characterized using FT-IR spectroscopy, elemental analysis, MALDI-TOF analysis and X-ray diffraction studies highlighting the formation of dinuclear species with various bridging ligands between the two copper(II) atoms and in some cases the dimerization of these species into tetranuclear complexes. The antioxidant, antimicrobial and antifungal activities of ligands and their copper(II) coordination complexes have been investigated. In particular, the complexes show similar or better antimicrobial and antifungal properties than the drugs commonly used in this field. The structure–biological activity relationship is discussed based on the nature of the ligand and the copper salt used in the synthesis of the complexes.

Graphical abstract: Synthesis, structure and biological properties of a series of dicopper(bis-thiosemicarbazone) complexes

Supplementary files

Article information

Article type
Paper
Submitted
21 Jan 2024
Accepted
05 Jun 2024
First published
05 Jun 2024

New J. Chem., 2024,48, 12043-12053

Synthesis, structure and biological properties of a series of dicopper(bis-thiosemicarbazone) complexes

D. Cebotari, S. Calancea, O. Garbuz, G. Balan, J. Marrot, S. Shova, V. Guérineau, D. Touboul, V. Tsapkov, A. Gulea and S. Floquet, New J. Chem., 2024, 48, 12043 DOI: 10.1039/D4NJ00342J

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