A copper(ii) bromide/NMO system for α-amination of esters under continuous-flow conditions with reduced catalyst loading

Abstract

A new copper(II) bromide/N-methylmorpholine N-oxide (NMO)-promoted method for α-amination of esters under continuous-flow conditions, with reduced catalyst loading is reported. The α-amino esters are precursors for the synthesis of α-amino acids. This method provides α-amino esters in 58–83% yields. The desired Cu(II)Br catalyst is regenerated by in situ oxidation of Cu(I)Br in the presence of NMO.