Issue 3, 2024

New cationic linear N-chloramines based on N-t-butylamide: chemical synthesis and antibacterial application

Abstract

For the first time, we synthesized three types of cationic linear N-chloramines that do not use the popular 5,5-dimethyl hydantoin scaffold. The characterized N-chloramines displayed satisfactory bactericidal activity, and the long-chain analogues exerted greatly elevated biocidal efficacy due to “synergistic” antibacterial actions between the N–Cl moiety and long chain cationic center. Our study provides highly efficacious biocides as well as paving the way for producing novel N-chloramines that exclude toxic cyanide salts.

Graphical abstract: New cationic linear N-chloramines based on N-t-butylamide: chemical synthesis and antibacterial application

Supplementary files

Article information

Article type
Communication
Submitted
02 Sep 2023
Accepted
12 Dec 2023
First published
18 Dec 2023

New J. Chem., 2024,48, 1076-1080

New cationic linear N-chloramines based on N-t-butylamide: chemical synthesis and antibacterial application

L. Li, S. Zhang, Z. Du, H. Wang and H. Zhou, New J. Chem., 2024, 48, 1076 DOI: 10.1039/D3NJ04005D

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