By using in situ Raman spectroscopy for reaction monitoring, we compare ball milling (BM) and resonant acoustic mixing (RAM) in the preparation α,β-unsaturated ketones (chalcones). RAM achieves similar transformations to BM, though adjustments in reaction conditions may be necessary due to different mixing regimes.
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L. Vugrin, C. Chatzigiannis, E. Colacino and I. Halasz, RSC Mechanochem., 2025, 2, 482 DOI: 10.1039/D5MR00016E
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