Issue 5, 2024

Unexpected reversal of reactivity in organic functionalities when immobilized together in a metal–organic framework (MOF)

Abstract

A mixed-ligand metal–organic framework (MOF) material composed of both amine- and hydroxyl-bearing linkers, KSU-1, was reacted with a variety of isocyanates. The hydroxyl groups reacted to a greater extent than the amines, in conflict with the previously observed relative nucleophilicities of these functionalities in the same MOF. When immobilized individually in monofunctional MOFs, the amine-functionalized linker was more reactive than the hydroxyl linker, indicating that the reactivity reversal observed in KSU-1 is due to the groups' mutual confinement within the MOF.

Graphical abstract: Unexpected reversal of reactivity in organic functionalities when immobilized together in a metal–organic framework (MOF)

Supplementary files

Article information

Article type
Communication
Submitted
27 Nov 2023
Accepted
15 Mar 2024
First published
19 Mar 2024

Mol. Syst. Des. Eng., 2024,9, 445-448

Unexpected reversal of reactivity in organic functionalities when immobilized together in a metal–organic framework (MOF)

P. Matseketsa, D. Mafukidze, L. Pothupitiya, U. P. Otuonye, Y. Ç. Mutlu, B. B. Averkiev and T. Gadzikwa, Mol. Syst. Des. Eng., 2024, 9, 445 DOI: 10.1039/D3ME00185G

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