Issue 6, 2024

Unveiling sultam in drug discovery: spotlight on the underexplored scaffold

Abstract

Decades ago, the application of cyclic sulfonamide (sultam) and its derivatives primarily focused on their antibacterial properties. However, recent years have seen a shift in research attention towards exploring their potential as anticancer, anti-inflammatory, antidiabetic, and antiviral agents. Despite this broadening scope, only a few sultam drugs have made it to the commercial market, as much of the research on sultams remains in the discovery phase. This class of compounds holds significant promise and remains pertinent in pharmaceutical research. Due to sultam's relevance and growing importance in drug discovery, this review paper aims to consolidate and examine the biological activities of sultam derivatives ranging from 4 to 8-membered ring structures.

Graphical abstract: Unveiling sultam in drug discovery: spotlight on the underexplored scaffold

Article information

Article type
Review Article
Submitted
21 Nov 2023
Accepted
14 Apr 2024
First published
16 Apr 2024

RSC Med. Chem., 2024,15, 1798-1827

Unveiling sultam in drug discovery: spotlight on the underexplored scaffold

Y. K. Chong, Y. S. Ong and K. Y. Yeong, RSC Med. Chem., 2024, 15, 1798 DOI: 10.1039/D3MD00653K

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