Issue 17, 2024

A concise protocol for the synthesis of 2-alkenylindoles through [4 + 1] annulation of aminobenzyl phosphonium salts with acrylaldehydes

Abstract

A [4 + 1] annulation protocol is developed for the synthesis of various 2-alkenylindole derivatives starting from aminobenzyl phosphonium salts and cinnamaldehydes. In this process, the reaction proceeds efficiently without the usage of any metal catalysts or base, and features available starting materials, a broad substrate scope, excellent yields and simple reaction conditions.

Graphical abstract: A concise protocol for the synthesis of 2-alkenylindoles through [4 + 1] annulation of aminobenzyl phosphonium salts with acrylaldehydes

Supplementary files

Article information

Article type
Communication
Submitted
13 Jun 2024
Accepted
19 Jul 2024
First published
25 Jul 2024

Green Chem., 2024,26, 9295-9299

A concise protocol for the synthesis of 2-alkenylindoles through [4 + 1] annulation of aminobenzyl phosphonium salts with acrylaldehydes

J. Yang, M. Liao, P. Li and L. Zou, Green Chem., 2024, 26, 9295 DOI: 10.1039/D4GC02859G

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