Issue 15, 2024

Individual and interaction effects of monounsaturated fatty acids on their associations with hypertension in Chinese residents

Abstract

Currently, associations between dietary intakes of individual monounsaturated fatty acids (MUFAs) and hypertension were not well disclosed, and the interaction effects of MUFAs on their associations with hypertension were unknown. Obesity was correlated with both MUFAs and hypertension, while if anthropometric obesity indices performed mediating roles in associations between MUFAs and hypertension remained underdetermined. In our study, 8509 Chinese adults investigated from 2004 to 2011 were included. Dietary information collection and physical examinations were performed at baseline and each timepoint of follow-up. As we found, inverse associations of MUFA17, MUFA18 and MUFA20 with hypertension were statistically significant after adjustments, hazard ratios (HRs) were 0.87, 0.90 and 0.91, respectively. MUFA15 was positively associated with hypertension, with an HR of 1.07 (95% confidence interval: 1.01, 1.12). By performing principal component analysis (PCA) to estimate the joint effects of MUFAs on hypertension, the PCA score of MUFAs was only inversely associated with blood pressure. No joint effect was observed in g-computation analyses. Both linear and nonlinear interactions of MUFAs on their associations with hypertension were estimated using restricted cubic spline analysis. The association between MUFA15 and hypertension was interacted by MUFA17, and the association between MUFA20 and hypertension was interacted by MUFA18. The mediation effects of body mass index and waist circumference were found on associations of hypertension with MUFA15, MUFA17 and MUFA20. Our findings suggested that associations with hypertension were different among individual MUFAs, and mutual interactions existed, implying that the utility of individual MUFAs might be recommended for estimating relationships between MUFAs and diseases. Moreover, fat accumulation might potentially underlie associations between MUFAs and hypertension.

Graphical abstract: Individual and interaction effects of monounsaturated fatty acids on their associations with hypertension in Chinese residents

Supplementary files

Article information

Article type
Paper
Submitted
26 Mar 2024
Accepted
23 Jun 2024
First published
24 Jun 2024

Food Funct., 2024,15, 7907-7919

Individual and interaction effects of monounsaturated fatty acids on their associations with hypertension in Chinese residents

Y. Liu, Y. Liang, X. Zhao, S. Ma, G. Sun and Y. Li, Food Funct., 2024, 15, 7907 DOI: 10.1039/D4FO01410C

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