Structural engineering of Pt-on-Rh hollow nanorods with high-performance peroxidase-like specific activity for colorimetric detection

Abstract

The preparation of nanozymes with high specific activity is highly important for various applications. However, only a few nanozymes have specific activities comparable to natural enzymes. Herein, novel Pt-on-Rh hollow nanorods (PtRh HNRs) were developed, in which surface Pt exhibited adjustable dispersity and interior Rh served as the support. The optimized PtRh HNRs demonstrated high-performance peroxidase (POD)-like activity, with a specific activity as high as 1352 U mg⁻¹, which was 3.86 times that of their monometallic Pt counterparts. Density functional theory (DFT) calculations illustrated that the presence of Rh decreased the energy barrier of the rate-determining step. When PtRh HNRs were used as nanozymes in the colorimetric detection of hydrogen peroxide (H₂O₂) and ascorbic acid (AA), the limits of detection (LODs) were as low as 9.97 μM and 0.039 μM, respectively. The current work highlights a facile and powerful strategy for manufacturing nanozymes with high specific activity and demonstrates that the prepared PtRh HNRs have the potential for analysis and determination.