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Dalton Transactions

A half sandwich Ru(ii)-p-cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant melanoma cells†

Yin-Hsuan Sun, ORCID logo a   Huey-Ling You,b   Manmath Narwane,a   Ru Xin Koi,c   Chai-Lin Kao, ORCID logo ad   Shyng-Shiou F. Yuan,dfg   Wei-Ting Liao,*e   Tsai-Te Lu ORCID logo *chi  and  Sodio C. N. Hsu ORCID logo *ad  

* Corresponding authors

a Department of Medicinal and Applied Chemistry, Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 807, Taiwan
E-mail: sodiohsu@kmu.edu.tw

b Department of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan

c Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan

d Translational Research Center, Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan

e Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan

f Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan

g Faculty and College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan

h Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan

i Department of Chemistry, Chung Yuan Christian University, Taoyuan 320, Taiwan

Abstract

The Ru(II)-nitrite complex, Ru4, is explored to release nitric oxide (NO) under acidic conditions and selectively induce a cytotoxic effect towards SK-MEL-28 cisplatin-resistant malignant melanoma cells. These findings suggest that targeting the tumor-associated pHe level could be an effective strategy for the drug function of Ru(II)-nitrite compounds.

Graphical abstract: A half sandwich Ru(ii)-p-cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant melanoma cells

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Article information

DOI
https://doi.org/10.1039/D4DT01012D
Article type
Paper
Submitted
06 Apr 2024
Accepted
04 Jun 2024
First published
10 Jun 2024

Dalton Trans., 2024, Advance Article

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A half sandwich Ru(II)-p-cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant melanoma cells

Y. Sun, H. You, M. Narwane, R. X. Koi, C. Kao, S. F. Yuan, W. Liao, T. Lu and S. C. N. Hsu, Dalton Trans., 2024, Advance Article , DOI: 10.1039/D4DT01012D

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