Issue 9, 2024

Supported Pd-catalyzed ring opening and chemoselective aminocarbonylative coupling of benzoxazoles with aryl iodides

Abstract

A tandem approach using polystyrene-supported palladium (Pd@PS) nanoparticles (NPs) catalyzed aminocarbonylative coupling of benzoxazole with aryl iodides to synthesize N-(2-hydroxyphenyl)benzamides has been devised. This protocol involves the ring opening of benzoxazole to 2-aminophenol followed by aminocarbonylative coupling with aryl iodides. Furthermore, the use of oxalic acid as a sustainable and inexpensive CO source, phosphine ligands-free, diverse substrate scope with appreciable yields, catalyst reusability, and gram scale applicability are important practical features.

Graphical abstract: Supported Pd-catalyzed ring opening and chemoselective aminocarbonylative coupling of benzoxazoles with aryl iodides

Supplementary files

Article information

Article type
Paper
Submitted
17 Jan 2024
Accepted
23 Feb 2024
First published
11 Mar 2024

Catal. Sci. Technol., 2024,14, 2416-2422

Supported Pd-catalyzed ring opening and chemoselective aminocarbonylative coupling of benzoxazoles with aryl iodides

P. Mehara, A. K. Sharma, A. Kumar, P. Sharma and P. Das, Catal. Sci. Technol., 2024, 14, 2416 DOI: 10.1039/D4CY00070F

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