Issue 5, 2024
From the journal:

Physical Chemistry Chemical Physics

A solid-state NMR method for characterization of pharmaceutical eutectics†

Chaithanya Hareendran,ab   Parth S. Shaligram,bc   Rajesh Gonnade ORCID logo bc  and  T. G. Ajithkumar ORCID logo *ab  

* Corresponding authors

a Central NMR facility and Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune 411008, India
E-mail: tg.ajithkumar@ncl.res.in

b Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

c Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune 411008, India

Abstract

Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions.

Graphical abstract: A solid-state NMR method for characterization of pharmaceutical eutectics

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Article information

DOI
https://doi.org/10.1039/D3CP05615E
Article type
Communication
Submitted
18 Nov 2023
Accepted
03 Jan 2024
First published
04 Jan 2024

Phys. Chem. Chem. Phys., 2024,26, 3800-3803

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A solid-state NMR method for characterization of pharmaceutical eutectics

C. Hareendran, P. S. Shaligram, R. Gonnade and T. G. Ajithkumar, Phys. Chem. Chem. Phys., 2024, 26, 3800 DOI: 10.1039/D3CP05615E

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