Issue 95, 2024

Extended polyene formation by a cryptic iterative polyketide synthase from Rhodococcus

Abstract

Many reactive intermediates leading to high value molecules are biosynthesised by multifunctional enzymes in Actinobacteria. Herein we report the workings of a cryptic iterative polyketide synthase (iPKS) from the marine microorganism Rhodococcus erythropolis PR4. The iPKS generates extended polyenes up to C22 nonaenes, preluding novel chemistry and biology.

Graphical abstract: Extended polyene formation by a cryptic iterative polyketide synthase from Rhodococcus

Supplementary files

Article information

Article type
Communication
Submitted
24 Sep 2024
Accepted
23 Oct 2024
First published
29 Oct 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 14085-14088

Extended polyene formation by a cryptic iterative polyketide synthase from Rhodococcus

P. Prasongpholchai, S. Tucker, C. Burgess, R. Jenkins, I. Wilkening, C. Corre, L. Song and M. Tosin, Chem. Commun., 2024, 60, 14085 DOI: 10.1039/D4CC04963B

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