Issue 91, 2024
From the journal:

Chemical Communications

Site-specific acetyl modification of 2′-OH of RNA by an oligonucleotide acetylating reagent†

Hirotaka Murase, ORCID logo *a   Mio Eto,a   Jeongsu Lee, ORCID logo b   Yosuke Taniguchi, ORCID logo c   Shuhei Imotoa  and  Shigeki Sasaki ORCID logo b  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, Japan
E-mail: murase@ph.sojo-u.ac.jp
Tel: +81-326-3985

b Graduate School of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch Machi, Sasebo 859-3298, Japan

c Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan

Abstract

The method for a site-specific RNA acetylation using a novel oligonucleotide acetylating probe (Ac-probe) has been developed. It was confirmed that the acetyl group was site-specifically introduced to a 2′-OH of the sugar part of the target RNA via the formation of the RNA-probe duplex.

Graphical abstract: Site-specific acetyl modification of 2′-OH of RNA by an oligonucleotide acetylating reagent

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Article information

DOI
https://doi.org/10.1039/D4CC04672B
Article type
Communication
Submitted
10 Sep 2024
Accepted
22 Oct 2024
First published
22 Oct 2024

Chem. Commun., 2024,60, 13440-13442

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Site-specific acetyl modification of 2′-OH of RNA by an oligonucleotide acetylating reagent

H. Murase, M. Eto, J. Lee, Y. Taniguchi, S. Imoto and S. Sasaki, Chem. Commun., 2024, 60, 13440 DOI: 10.1039/D4CC04672B

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