Issue 98, 2024
From the journal:

Chemical Communications

Palladium-catalyzed cascade cyclization of isocyanides with di-(o-iodophenyl)sulfonylguanidines: access to heterocyclic fused quinazolines†

Shen Ge,a   Yi-Ming Zhu,a   Xiao-Ping Xu, ORCID logo *ab   You Zi ORCID logo *c  and  Shun-Jun Ji ORCID logo *a  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, P. R. China
E-mail: xuxp@suda.edu.cn, shunjun@suda.edu.cn

b Innovation Center for Chemical Science, Soochow University, Suzhou 215123, P. R. China

c School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, P. R. China
E-mail: ziyou@ntu.edu.cn

Abstract

A palladium-catalyzed cascade cyclization reaction of di-o-iodophenyl sulfonylguanidines with isocyanides for the efficient and selective synthesis of 5- or 6-membered heterocyclic fused quinazolines has been developed. Diverse functional groups are well tolerated, and this method has been successfully applied to a larger scale synthesis.

Graphical abstract: Palladium-catalyzed cascade cyclization of isocyanides with di-(o-iodophenyl)sulfonylguanidines: access to heterocyclic fused quinazolines

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Article information

DOI
https://doi.org/10.1039/D4CC04084H
Article type
Communication
Submitted
11 Aug 2024
Accepted
05 Nov 2024
First published
18 Nov 2024

Chem. Commun., 2024,60, 14613-14616

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Palladium-catalyzed cascade cyclization of isocyanides with di-(o-iodophenyl)sulfonylguanidines: access to heterocyclic fused quinazolines

S. Ge, Y. Zhu, X. Xu, Y. Zi and S. Ji, Chem. Commun., 2024, 60, 14613 DOI: 10.1039/D4CC04084H

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