Weixiang Li, Ruipu Zhang, Naifu Zhou, Jiaqing Lu and Niankai Fu
Chem. Commun., 2024,60, 11714-11717
DOI:
10.1039/D4CC04036H,
Communication
We report a dual transition metal electrocatalytic approach for C(sp3)–C(sp3) bond cleavage and arylation of cyclic alcohols, providing an efficient and sustainable method for site-specific arylation of ketones. The reaction involves electrophotochemical cerium-catalysed generation of alkoxyl radicals from readily accessible alcohols. Subsequently, homolytic cleavage of the β-C–C bond leads to the generation of carbon-centered radicals that could be effectively utilized by nickel catalysis powered by cathode reduction to deliver the remote arylated ketone products.