Long-wavelength triggered iridium(III) complex nanoparticles for photodynamic therapy against hypoxic cancer

Shengnan Liu; Ziwei Wang; Zihan Wu; Haoran Chen; Dongxia Zhu; Gungzhe Li; Mingming Yan; Martin R. Bryce; Yulei Chang

doi:10.1039/D4CC03501A

Long-wavelength triggered iridium(iii) complex nanoparticles for photodynamic therapy against hypoxic cancer†

Shengnan Liu,

^a Ziwei Wang,^a Zihan Wu,^a Haoran Chen,^b Dongxia Zhu,

*^a Gungzhe Li,*^c Mingming Yan,^c Martin R. Bryce

*^d and Yulei Chang

*^b

Author affiliations

* Corresponding authors

^a Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province 130024, P. R. China
E-mail: zhudx047@nenu.edu.cn

^b State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin Province 130033, China
E-mail: yuleichang@ciomp.ac.cn

^c Jilin Provincial Science and Technology Innovation Center of Health Food of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province 130117, P. R. China
E-mail: 1993008106@qq.com

^d Department of Chemistry, Durham University, Durham, UK
E-mail: m.r.bryce@durham.ac.uk

Abstract

A long-wavelength triggered cationic iridium(III) complex, Ir5, and its corresponding nanoparticles with the ability to generate type I and type II reactive oxygen species have been synthesised. The complex targets mitochondria and achieves an excellent photodynamic therapy effect in hypoxic cancer cells.

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DOI: https://doi.org/10.1039/D4CC03501A
Article type: Communication
Submitted: 13 Jul 2024
Accepted: 12 Aug 2024
First published: 22 Aug 2024
This article is Open Access

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Chem. Commun., 2024,60, 9938-9941

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Long-wavelength triggered iridium(III) complex nanoparticles for photodynamic therapy against hypoxic cancer

S. Liu, Z. Wang, Z. Wu, H. Chen, D. Zhu, G. Li, M. Yan, M. R. Bryce and Y. Chang, Chem. Commun., 2024, 60, 9938 DOI: 10.1039/D4CC03501A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Communications

Long-wavelength triggered iridium(iii) complex nanoparticles for photodynamic therapy against hypoxic cancer†

Abstract

Supplementary files

Article information

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Long-wavelength triggered iridium(III) complex nanoparticles for photodynamic therapy against hypoxic cancer

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