Issue 73, 2024
From the journal:

Chemical Communications

Long-wavelength triggered iridium(iii) complex nanoparticles for photodynamic therapy against hypoxic cancer†

Shengnan Liu, ORCID logo a   Ziwei Wang,a   Zihan Wu,a   Haoran Chen,b   Dongxia Zhu, ORCID logo *a   Gungzhe Li,*c   Mingming Yan,c   Martin R. Bryce ORCID logo *d  and  Yulei Chang ORCID logo *b  

* Corresponding authors

a Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province 130024, P. R. China
E-mail: zhudx047@nenu.edu.cn

b State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin Province 130033, China
E-mail: yuleichang@ciomp.ac.cn

c Jilin Provincial Science and Technology Innovation Center of Health Food of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province 130117, P. R. China
E-mail: 1993008106@qq.com

d Department of Chemistry, Durham University, Durham, UK
E-mail: m.r.bryce@durham.ac.uk

Abstract

A long-wavelength triggered cationic iridium(III) complex, Ir5, and its corresponding nanoparticles with the ability to generate type I and type II reactive oxygen species have been synthesised. The complex targets mitochondria and achieves an excellent photodynamic therapy effect in hypoxic cancer cells.

Graphical abstract: Long-wavelength triggered iridium(iii) complex nanoparticles for photodynamic therapy against hypoxic cancer

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Article information

DOI
https://doi.org/10.1039/D4CC03501A
Article type
Communication
Submitted
13 Jul 2024
Accepted
12 Aug 2024
First published
22 Aug 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 9938-9941

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Long-wavelength triggered iridium(III) complex nanoparticles for photodynamic therapy against hypoxic cancer

S. Liu, Z. Wang, Z. Wu, H. Chen, D. Zhu, G. Li, M. Yan, M. R. Bryce and Y. Chang, Chem. Commun., 2024, 60, 9938 DOI: 10.1039/D4CC03501A

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