Issue 83, 2024

Dye self-organization in doped silica nanoparticles increases the electrochemiluminescence emission in magnetic bead-based assays

Abstract

We have investigated the effect of dye distribution on the electrochemiluminescence (ECL) intensity measured with a simplified magnetic bead-based immunoassay for two families of silica nanoparticles (NPs) doped with the cationic Ru(bpy)32+ and the zwitterionic Ru(bpy)2bps complexes (bps = bathophenanthroline disulfonate). The NPs doped with the Ru(bpy)2bps complex, which can efficiently self-organize in the NP volume favoring ECL generation, resulted in 150–400% signal enhancement compared to the Ru(bpy)32+-doped ones.

Graphical abstract: Dye self-organization in doped silica nanoparticles increases the electrochemiluminescence emission in magnetic bead-based assays

Supplementary files

Article information

Article type
Communication
Submitted
12 Jul 2024
Accepted
23 Sep 2024
First published
23 Sep 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 11936-11939

Dye self-organization in doped silica nanoparticles increases the electrochemiluminescence emission in magnetic bead-based assays

Y. A. Alemu, M. Difonzo, D. Genovese, F. Paolucci, L. Prodi, E. Rampazzo and G. Valenti, Chem. Commun., 2024, 60, 11936 DOI: 10.1039/D4CC03488K

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