Issue 78, 2024

Biosynthesis of multifunctional transformable peptides for downregulation of PD-L1

Abstract

Here, we present a biosynthesized material M1 for immune checkpoint blocking therapy. M1 could realize a morphological transformation from globular to fibrous in situ in the presence of cathepsin B (CtsB) after entering tumor cells. The GO203 peptides of M1 are exposed, which could bind to mucin 1 (MUC1) to suppress the homodimerization process of MUC1, thereby downregulating PD-L1 expression.

Graphical abstract: Biosynthesis of multifunctional transformable peptides for downregulation of PD-L1

Supplementary files

Article information

Article type
Communication
Submitted
28 Jun 2024
Accepted
02 Sep 2024
First published
03 Sep 2024
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2024,60, 10938-10941

Biosynthesis of multifunctional transformable peptides for downregulation of PD-L1

Y. Di, Z. Yang, G. Song, Q. Shen, H. Bai, Y. Huang, F. Lv and S. Wang, Chem. Commun., 2024, 60, 10938 DOI: 10.1039/D4CC03146F

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