Issue 62, 2024

Visible-light promoted radical cascade cyclization of 3-allyl-2-arylquinazolinones for the synthesis of phosphorylated dihydroisoquinolino[1,2-b]quinazolinones

Abstract

A novel visible-light promoted metal-free radical cascade cyclization reaction has been developed with 3-allyl-2-arylquinazolinones as a new class of radical acceptor. This photocatalytic protocol represents an efficient approach to construct phosphorylated dihydroisoquinolino[1,2-b]quinazolinones featuring mild conditions, broad substrate scope, and gram-scale synthesis.

Graphical abstract: Visible-light promoted radical cascade cyclization of 3-allyl-2-arylquinazolinones for the synthesis of phosphorylated dihydroisoquinolino[1,2-b]quinazolinones

Supplementary files

Article information

Article type
Communication
Submitted
16 Jun 2024
Accepted
04 Jul 2024
First published
08 Jul 2024

Chem. Commun., 2024,60, 8119-8122

Visible-light promoted radical cascade cyclization of 3-allyl-2-arylquinazolinones for the synthesis of phosphorylated dihydroisoquinolino[1,2-b]quinazolinones

J. Huang, C. Ban, J. Qin, J. Xu, Y. Gu, L. Wei, J. Yuan and G. Huang, Chem. Commun., 2024, 60, 8119 DOI: 10.1039/D4CC02915A

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