Sensitive subcellular scale and real-time detection of hydrogen peroxide by a W-doped Pt microelectrode

Shaohui Lei; Zhuo Zou; Kangling Tian; Yan Zheng; Mei Ding; Guangxuan Hu; Hong Bin Yang; Chunxian Guo; Changming Li; Fang Xin Hu

doi:10.1039/D4CC02835J

Sensitive subcellular scale and real-time detection of hydrogen peroxide by a W-doped Pt microelectrode†

Shaohui Lei,^a Zhuo Zou,^a Kangling Tian,^a Yan Zheng,^a Mei Ding,^a Guangxuan Hu,^a Hong Bin Yang,^a Chunxian Guo,

^a Changming Li*^a and Fang Xin Hu

*^a

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* Corresponding authors

^a School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China
E-mail: ecmli@mail.usts.edu.cn, hufx278@usts.edu.cn

Abstract

A W-doped Pt modified graphene oxide (Pt-W-GO) electrochemical microelectrode was developed to detect hydrogen peroxide (H₂O₂) in real time at a subcellular scale. Interestingly, results showed that the concentration of H₂O₂ in the nucleus of HeLa cells was 2.68 times and 0.51 times that in the extracellular membrane and cytoplasm, respectively.

Chemical Communications

Sensitive subcellular scale and real-time detection of hydrogen peroxide by a W-doped Pt microelectrode†

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Sensitive subcellular scale and real-time detection of hydrogen peroxide by a W-doped Pt microelectrode

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