Issue 65, 2024

Pd-Catalyzed cascade Heck cyclization/carbonylation of indoles with aryl formates: enantioselective construction of indolo[2,1-a]isoquinolines

Abstract

An efficient palladium-catalyzed cascade cyclization/carbonylation of indoles with aryl formates to access ester-functionalized indolo[2,1-a]isoquinoline scaffolds has been developed. In addition, an asymmetric variant is also achieved using a chiral phosphine ligand, affording the indolo[2,1-a]isoquinoline products in good yields and enantioselectivities.

Graphical abstract: Pd-Catalyzed cascade Heck cyclization/carbonylation of indoles with aryl formates: enantioselective construction of indolo[2,1-a]isoquinolines

Supplementary files

Article information

Article type
Communication
Submitted
28 May 2024
Accepted
17 Jul 2024
First published
18 Jul 2024

Chem. Commun., 2024,60, 8613-8616

Pd-Catalyzed cascade Heck cyclization/carbonylation of indoles with aryl formates: enantioselective construction of indolo[2,1-a]isoquinolines

D. Chi, H. Qi, L. Wang and S. Chen, Chem. Commun., 2024, 60, 8613 DOI: 10.1039/D4CC02577F

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