Synthesis of macrocyclic thiolactone peptides via photochemical intramolecular radical acyl thiol–ene ligation†
Alby
Benny 
a
and
Eoin M.
Scanlan
*a
a
and
Eoin M.
Scanlan
*a
Abstract
A photochemical acyl thiol–ene reaction can be used to rapidly cyclise fully unprotected peptides bearing both a thioacid and alkene to form peptide thiolactones. This strategy represents the first reported synthesis of peptide thiolactones under radical-mediated conditions.
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