Issue 63, 2024

Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence imaging-guided photodynamic therapy

Abstract

This study describes H2O2-activated photosensitizer nanoparticles (ICyHD NPs), which inhibit histone deacetylase via binding Zn2+ to induce ferroptosis and upregulate the intracellular O2, thus resulting in enhanced photodynamic therapeutic effect. ICyHD NPs exert strong antitumor effects on mice and have improved the therapeutic precision via observing the increase in cellular fluorescence.

Graphical abstract: Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence imaging-guided photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
23 May 2024
Accepted
08 Jul 2024
First published
09 Jul 2024

Chem. Commun., 2024,60, 8248-8251

Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence imaging-guided photodynamic therapy

L. Zhang, M. He, X. Xia, Z. Ma, C. Lv, R. Wang, W. Liu, J. Fan, X. Peng and W. Sun, Chem. Commun., 2024, 60, 8248 DOI: 10.1039/D4CC02391A

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