Issue 60, 2024

A dual-labeling fluorescent probe to track lysosomal polarity and endoplasmic reticulum dynamics during ferroptosis

Abstract

A polarity-sensitive probe was developed to simultaneously label lysosomes and endoplasmic reticulum (ER) via its dansylamide and rhodamine fluorescence, respectively, enabling ratiometric polarity detection and stable dual-labeling. The fragmented ER network and increased lysosomal polarity during ferroptosis were revealed, which facilitates the understanding of ferroptotic mechanisms.

Graphical abstract: A dual-labeling fluorescent probe to track lysosomal polarity and endoplasmic reticulum dynamics during ferroptosis

Supplementary files

Article information

Article type
Communication
Submitted
06 May 2024
Accepted
24 Jun 2024
First published
26 Jun 2024

Chem. Commun., 2024,60, 7773-7776

A dual-labeling fluorescent probe to track lysosomal polarity and endoplasmic reticulum dynamics during ferroptosis

Z. Zhao, W. Jin, M. Wu, Q. Lin and Y. Duan, Chem. Commun., 2024, 60, 7773 DOI: 10.1039/D4CC02161D

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