Issue 56, 2024

Visible-light-induced photocatalyst-free cascade cyclization of 3-(2-(ethynyl)phenyl)quinazolinones to sulfonated quinolino[2,1-b]quinazolinones

Abstract

A visible-light-induced K2S2O8-promoted cascade sulfonation/cyclization reaction was established using 3-(2-(ethynyl)phenyl)quinazolinones as efficient substrates under mild conditions. A series of sulfonated quinolino[2,1-b]quinazolinones were successfully synthesized under transition-metal- and photocatalyst-free conditions. Notably, this strategy has the advantages of room temperature and simple operation, easy scale-up, and good functional group tolerance.

Graphical abstract: Visible-light-induced photocatalyst-free cascade cyclization of 3-(2-(ethynyl)phenyl)quinazolinones to sulfonated quinolino[2,1-b]quinazolinones

Supplementary files

Article information

Article type
Communication
Submitted
25 Apr 2024
Accepted
14 Jun 2024
First published
17 Jun 2024

Chem. Commun., 2024,60, 7228-7231

Visible-light-induced photocatalyst-free cascade cyclization of 3-(2-(ethynyl)phenyl)quinazolinones to sulfonated quinolino[2,1-b]quinazolinones

F. Zeng, L. Wang, Y. Luo, J. Chen, J. Li and J. Yuan, Chem. Commun., 2024, 60, 7228 DOI: 10.1039/D4CC01970A

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