Issue 48, 2024
From the journal:

Chemical Communications

Programmably engineered stochastic RNA nanowalker for ultrasensitive miRNA detection†

Dan Zhu, ORCID logo ab   Dongxia Zhao,a   Yang Hu,a   Tianhui Wei,a   Tong Su,a   Shao Su, ORCID logo a   Jie Chao ORCID logo a  and  Lianhui Wang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China
E-mail: iamlhwang@njupt.edu.cn

b State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China

Abstract

A programmably engineered stochastic RNA nanowalker powered by duplex-specific nuclease (DSN) is developed. By utilizing poly-adenine-based spherical nucleic acids (polyA-SNA) to accurately regulate the densities of DNA tracks, the nanowalker showcases its capability to identify miRNA-21, miRNA-486, and miRNA-155 with quick kinetics and attomolar sensitivity, positioning it as a promising option for cancer clinical surveillance.

Graphical abstract: Programmably engineered stochastic RNA nanowalker for ultrasensitive miRNA detection

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D4CC01656D
Article type
Communication
Submitted
09 Apr 2024
Accepted
17 May 2024
First published
20 May 2024

Chem. Commun., 2024,60, 6142-6145

Permissions

Request permissions

Programmably engineered stochastic RNA nanowalker for ultrasensitive miRNA detection

D. Zhu, D. Zhao, Y. Hu, T. Wei, T. Su, S. Su, J. Chao and L. Wang, Chem. Commun., 2024, 60, 6142 DOI: 10.1039/D4CC01656D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements