We developed a system to detect multiple target biomolecules through sensing motif-tethered oligodeoxynucleotides. DNA-based molecular probes gave the primary amine motif upon reaction with the target biomolecules, glutathione (GSH) and H2O2. After labelling with biotin, the product DNAs were selectively collected to be quantified by qPCR.
T. Nishihara, Y. Motohashi, R. Mio, M. Sugawara and K. Tanabe, Chem. Commun., 2024, 60, 6059 DOI: 10.1039/D4CC01470G
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