A GalNAc-modified CaCO3 nano-immunomodulator for targeted and responsive immunotherapy against orthotopic liver cancer

Yanhua Li; Jiaqi Yin; Jiarui Zhong; Wei Pan; Na Li; Bo Tang

doi:10.1039/D4CC01207K

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A GalNAc-modified CaCO₃ nano-immunomodulator for targeted and responsive immunotherapy against orthotopic liver cancer†

Yanhua Li,‡^a Jiaqi Yin,‡^a Jiarui Zhong,^a Wei Pan,

^a Na Li

*^a and Bo Tang

*^ab

Author affiliations

* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, P. R. China
E-mail: lina@sdnu.edu.cn, tangb@sdnu.edu.cn

^b Laoshan Laboratory, Qingdao, P. R. China

Abstract

A nano-immunomodulator modified with N-acetylgalactosamine (GalNAc) on calcium carbonate (CaCO₃) was prepared for targeted and responsive immunotherapy. And the immunologic adjuvant (CpG ODNs) and doxorubicin (DOX) were released to synergistically improve immune response for treating orthotopic liver cancer.

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Article information

DOI: https://doi.org/10.1039/D4CC01207K
Article type: Communication
Submitted: 16 Mar 2024
Accepted: 03 Jul 2024
First published: 04 Jul 2024

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Chem. Commun., 2024,60, 8103-8106

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A GalNAc-modified CaCO₃ nano-immunomodulator for targeted and responsive immunotherapy against orthotopic liver cancer

Y. Li, J. Yin, J. Zhong, W. Pan, N. Li and B. Tang, Chem. Commun., 2024, 60, 8103 DOI: 10.1039/D4CC01207K

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Chemical Communications