Issue 61, 2024

Ligand-free 99mTc-polyurea dendrimer complexes: nanoradiotheranostics targeting ovarian cancer

Abstract

A folic acid-targeted polyurea (PURE) dendrimer was easily radiolabelled with Technetium-99m (99mTc-PUREG4-FA2) avoiding the use of additional ligands and bioconjugation chemistry. This straightforward strategy is enabled in PURE dendrimers due to their favourable surface terminal groups configuration, showing coordination capabilities and turning these biodendrimers into attractive platforms for nanoradiotheranostics.

Graphical abstract: Ligand-free 99mTc-polyurea dendrimer complexes: nanoradiotheranostics targeting ovarian cancer

Supplementary files

Article information

Article type
Communication
Submitted
24 Feb 2024
Accepted
13 May 2024
First published
13 May 2024

Chem. Commun., 2024,60, 7874-7877

Ligand-free 99mTc-polyurea dendrimer complexes: nanoradiotheranostics targeting ovarian cancer

A. Cruz, R. F. Pires, P. Raposinho, C. Fernandes, A. Paulo and V. D.B. Bonifácio, Chem. Commun., 2024, 60, 7874 DOI: 10.1039/D4CC00892H

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