Issue 20, 2024
From the journal:

Chemical Communications

Detection and discrimination of glutathione among biological thiols based on oxalyl dihydrazide decorated sulfur nanodots†

Yifei Xing,a   Sha Zhu,b   Jiayue Li,c   Wei Li, ORCID logo c   Zhenguang Wang ORCID logo *a  and  Yu-e Shi*a  

* Corresponding authors

a State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Analytical Science and Technology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, College of Chemistry and Materials Science, Hebei University, Baoding 071002, P. R. China
E-mail: zgwang@hbu.edu.cn, shiyue1220@163.com

b Sanitary Inspection Department of Zibo Center for Disease Control and Prevention, Zibo, Shandong 255026, China

c College of Pharmaceutical Science, Hebei University, Baoding, P. R. China

Abstract

The quantitative detection and discrimination of glutathione (GSH) were achieved based on oxalyl dihydrazide (ODH) decorated sulfur nanodots. ODH resulted in the aggregation and fluorescence quenching of the sulfur nanodots, and GSH selectively triggered fluorescence recovery through forming stronger hydrogen bonds with ODH than other biological thiols.

Graphical abstract: Detection and discrimination of glutathione among biological thiols based on oxalyl dihydrazide decorated sulfur nanodots

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Article information

DOI
https://doi.org/10.1039/D4CC00135D
Article type
Communication
Submitted
10 Jan 2024
Accepted
31 Jan 2024
First published
07 Feb 2024

Chem. Commun., 2024,60, 2760-2763

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Detection and discrimination of glutathione among biological thiols based on oxalyl dihydrazide decorated sulfur nanodots

Y. Xing, S. Zhu, J. Li, W. Li, Z. Wang and Y. Shi, Chem. Commun., 2024, 60, 2760 DOI: 10.1039/D4CC00135D

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