Ionic liquid-mediated ethosome for transdermal delivery of insulin

Fahmida Habib Nabila; Rashedul Islam; Islam Md Shimul; Muhammad Moniruzzaman; Rie Wakabayashi; Noriho Kamiya; Masahiro Goto

doi:10.1039/D3CC06130B

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Ionic liquid-mediated ethosome for transdermal delivery of insulin†

Fahmida Habib Nabila,

^a Rashedul Islam,

^a Islam Md Shimul,^b Muhammad Moniruzzaman,

^c Rie Wakabayashi,^ade Noriho Kamiya

^ade and Masahiro Goto

*^a

Author affiliations

* Corresponding authors

^a Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
E-mail: m-goto@mail.cstm.kyushu-u.ac.jp

^b Department of Nutrition and Food Technology, Jashore University of Science and Technology, Jashore-7408, Bangladesh

^c Department of Chemical Engineering, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia

^d Advanced Transdermal Drug Delivery System Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan

^e Division of Biotechnology, Center for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan

Abstract

Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability.

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Article information

DOI: https://doi.org/10.1039/D3CC06130B
Article type: Communication
Submitted: 20 Dec 2023
Accepted: 06 Mar 2024
First published: 06 Mar 2024
This article is Open Access

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Chem. Commun., 2024,60, 4036-4039

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Ionic liquid-mediated ethosome for transdermal delivery of insulin

F. H. Nabila, R. Islam, I. M. Shimul, M. Moniruzzaman, R. Wakabayashi, N. Kamiya and M. Goto, Chem. Commun., 2024, 60, 4036 DOI: 10.1039/D3CC06130B

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Chemical Communications

Ionic liquid-mediated ethosome for transdermal delivery of insulin†

Abstract

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Ionic liquid-mediated ethosome for transdermal delivery of insulin

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