Dual-targets fluorescent nanoprobe for precise subtyping of lung cancer

Abstract

A Au–Se bond-based nanoprobe using 3′,3-diselenopropionic acid to simultaneously link response chains for Pro-GRP protein and Cyfra21-1 was developed. Early diagnosis and subtyping of lung cancer can be achieved based on the nanoprobes’ differential response of the probes to the two targets in lung cancer patients’ serum.