Issue 6, 2024

First atroposelective Chan–Lam coupling for the synthesis of C–N linked biaryls

Abstract

The first atroposelective Chan–Lam coupling for the synthesis of C–N axial enantiomers is reported with good yields and ee. MnO2 additive is crucial for the success of the coupling. The longstanding problem of the lack of enantioselective synthesis to make chiral C–N linked atropisomers is solved.

Graphical abstract: First atroposelective Chan–Lam coupling for the synthesis of C–N linked biaryls

Supplementary files

Article information

Article type
Communication
Submitted
04 Nov 2023
Accepted
16 Dec 2023
First published
19 Dec 2023

Chem. Commun., 2024,60, 678-681

First atroposelective Chan–Lam coupling for the synthesis of C–N linked biaryls

M. Ishida, R. Adachi, K. Kobayashi, Y. Yamamoto, C. Kawahara, T. Yamada, H. Aoyama, K. Kanomata, S. Akai, P. Y. S. Lam, H. Sajiki and T. Ikawa, Chem. Commun., 2024, 60, 678 DOI: 10.1039/D3CC05447K

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