Issue 4, 2024

Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

Abstract

A nickel-catalyzed hydrogen isotope exchange has been developed with acetone-d6 as the deuterium source. The reaction showed an improved kinetic feature of H/D exchange under the assistance of 2-pyridones, efficiently affording regioselective labeled aryl and alkyl carboxamides.

Graphical abstract: Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

Supplementary files

Article information

Article type
Communication
Submitted
26 Oct 2023
Accepted
17 Nov 2023
First published
27 Nov 2023

Chem. Commun., 2024,60, 384-387

Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

Z. Jiang, S. Xu, Y. Su, E. Hu, J. Han, J. Bai, B. Tang, J. Chen and Z. Gao, Chem. Commun., 2024, 60, 384 DOI: 10.1039/D3CC05257E

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