Issue 8, 2024
From the journal:

Chemical Communications

Peptide coupling using recyclable bicyclic benziodazolone†

Daigo Uehara,a   Sota Adachi,b   Akira Tsubouchi,a   Yohei Okada, ORCID logo b   Viktor V. Zhdankin, ORCID logo c   Akira Yoshimura ORCID logo d  and  Akio Saito ORCID logo *a  

* Corresponding authors

a Division of Applied Chemistry, Institute of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan
E-mail: akio-sai@cc.tuat.ac.jp

b Department of Applied Biological Science, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan

c Department of Chemistry and Biochemistry, University of Minnesota, Duluth, MN, USA

d Faculty of Pharmaceutical Sciences, Aomori University, 2-3-1 Kobata, Aomori 030-0943, Japan

Abstract

We report a greener peptide coupling using bicyclic benziodazolone and triarylphosphine as coupling reagents. Bicyclic benziodazolone also works as a base and can be recovered as the corresponding iodine(I) compound after use, which can be converted to the original iodine(III) reagent by electrolytic oxidation.

Graphical abstract: Peptide coupling using recyclable bicyclic benziodazolone

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D3CC04431A
Article type
Communication
Submitted
07 Sep 2023
Accepted
18 Dec 2023
First published
18 Dec 2023

Chem. Commun., 2024,60, 956-959

Author version available


Download author version (PDF)

Permissions

Request permissions

Peptide coupling using recyclable bicyclic benziodazolone

D. Uehara, S. Adachi, A. Tsubouchi, Y. Okada, V. V. Zhdankin, A. Yoshimura and A. Saito, Chem. Commun., 2024, 60, 956 DOI: 10.1039/D3CC04431A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements