From bone to nacre - development of biomimetic materials for bone implants: a review

Abstract

The field of bone repair and regeneration has undergone significant advancements, yet challenges persist in achieving optimal bone implants or scaffolds, particularly load-bearing bone implants. This review explores the current landscape of bone implants, emphasizing the complexity of bone anatomy and the emerging paradigm of biomimicry inspired by natural structures. Nature, as a master architect, offers insights into the design of biomaterials that can closely emulate the mechanical properties and hierarchical organization of bone. By drawing parallels with nacre, the mollusk shells renowned for their exceptional strength and toughness, researchers have endeavored to develop bone implants with enhanced biocompatibility and mechanical robustness. This paper surveys the literature on various nacre-inspired composites, particularly ceramic/polymer composites like calcium phosphate (CaP), which exhibit promising similarities to native bone tissue. By harnessing the principles of hierarchical organization and organic-inorganic interfaces observed in natural structures, researchers aim to overcome existing limitations in bone implant technology, paving the way for more durable, biocompatible, and functionally integrated solutions in orthopedic and dental applications.