Microwave-Assisted Fabrication of Nanostructured Borate Bioactive Glass and its Bioactivity

Abstract

Sol-gel synthesized bioactive glass with nanostructures has demonstrated enhanced bioactivity and acceptance by bone tissue compared to silicate glasses. Borate bioactive glasses exhibit higher reactivity and apatite formation in simulated body fluid in contrast to silicate glasses. This study presents a microwave-assisted synthesis of borate bioactive glass (58S). The nanocrystalline structures within the amorphous matrix regulate the degradation rate of the glass network and facilitate neovascularization. The calcinated borate bioactive glass features a nanorod crystalline hydroxyapatite structure embedded in the amorphous borate glass network. Apatite the formation within 6 hours of immersion in simulated body fluid validates its heightened reactivity and bioactivity. Anti-oxidant studies, cell viability, and alkaline phosphate activity further corroborate the bioactivity of borate bioactive glass. In summary, this study highlights the significant potential of microwave-synthesized borate bioactive glass for a wide range of bone tissue engineering applications