Issue 32, 2024

Chiral metal–organic frameworks grown in situ for monolithic capillary electrochromatographic enantioseparation

Abstract

Chiral metal–organic frameworks (CMOFs) with chiral selectivity are one of the high-quality stationary phases for capillary electrochromatography (CEC). However, there is a problem of unsatisfactory enantioseparation performance of capillary columns due to insufficient loading. In this work, a lamellar CMOF (Cu-TC) was grown in situ on the surface of the monolith in a capillary monolithic column to obtain a Cu-TC@monolithic column. The CEC system constructed based on the Cu-TC@monolithic column shows a satisfactory chiral separation performance. Compared with the Cu-TC-based coated column (Cu-TC@coated column), the enantioseparation performance of the CEC system based on the Cu-TC@monolithic column was greatly improved, and the resolutions (Rs) of the model analytes were increased by 80–500%. In addition, the effects of experimental conditions such as the number of cycles of Cu-TC in situ growth, buffer concentration, buffer pH, organic solvent addition and applied voltage on the performance of CEC were also investigated. Finally, the chiral selection mechanism of the stationary phase was explored by selective adsorption experiments. The present work provides a new idea for the development of capillary stationary phases, which has great potential considering the diversity of CMOFs.

Graphical abstract: Chiral metal–organic frameworks grown in situ for monolithic capillary electrochromatographic enantioseparation

Supplementary files

Article information

Article type
Paper
Submitted
27 May 2024
Accepted
02 Jul 2024
First published
05 Jul 2024

Anal. Methods, 2024,16, 5545-5554

Chiral metal–organic frameworks grown in situ for monolithic capillary electrochromatographic enantioseparation

M. Zhou, J. Hao, Y. Wu, X. Lu, J. Song, L. Ren and J. Han, Anal. Methods, 2024, 16, 5545 DOI: 10.1039/D4AY00990H

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