An account on current status of Point-of-Care Lateral Flow Tests for Kidney Biomarker detection

Abstract

Globally, the primary causes of mortality and morbidity related to kidney ailments can be classified as Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD). Biomarkers detection can have great potential to improve the survival, lower the mortality, and reduce the cost of treatment of kidney diseases. Considering the chronic nature of CKD non-invasive identification and monitoring has proven to be useful. Biosensors and more specifically the lateral flow test strips (LFTs) are regarded as the most desirable point-of-care instruments which have shown promise in elevating the healthcare industry to a new level. The major aspects of an ideal point-of-care (POC) lateral flow tests include its cost effectiveness, high sensitivity and specificity, ease of use, quick result delivery, and quality control. This review provides a detailed account of recent developments, challenges, and opportunities in renal biomarker detection by LFTS including various approaches of sensitivity enhancement along with potential future advancements in POC and LFT kits.