Issue 3, 2024

Two-step, high-yielding total synthesis of antibiotic pyrones

Abstract

A simple two-step dialkylation protocol was developed to synthesize biologically active antibiotics photopyrones, pseudopyronines, and violapyrones from bio-renewable triacetate lactone in excellent yields. These pyrones are functionally modified into another set of pyrone natural products by a single O-methylation reaction. The high-yielding gram scale synthesis of four natural products [pseudopyronine A, photopyrone A, pseudopyronine B and photopyrone C] demonstrated the viability for industrial applications.

Graphical abstract: Two-step, high-yielding total synthesis of antibiotic pyrones

Supplementary files

Article information

Article type
Paper
Submitted
25 Nov 2023
Accepted
13 Dec 2023
First published
14 Dec 2023

Org. Biomol. Chem., 2024,22, 554-560

Two-step, high-yielding total synthesis of antibiotic pyrones

A. Hussain, R. Sravanthi, S. Katta and D. B. Ramachary, Org. Biomol. Chem., 2024, 22, 554 DOI: 10.1039/D3OB01923C

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