Issue 39, 2023

Comprehensive evaluation and advanced modification of polymethylmethacrylate cement in bone tumor treatment

Abstract

Bone tumors are invasive diseases with a tendency toward recurrence, disability, and high mortality rates due to their grievous complications. As a commercial polymeric biomaterial, polymethylmethacrylate (PMMA) cement possesses remarkable mechanical properties, injectability, and plasticity and is, therefore, frequently applied in bone tissue engineering. Numerous positive effects in bone tumor treatment have been demonstrated, including biomechanical stabilization, analgesic effects, and tumor recurrence prevention. However, to our knowledge, a comprehensive evaluation of the application of the PMMA cement in bone tumor treatment has not yet been reported. This review comprehensively evaluates the efficiency and complications of the PMMA cement in bone tumor treatment, for the first time, and introduces advanced modification strategies, providing an objective and reliable reference for the application of the PMMA cement in treating bone tumors. We have also summarized the current research on modifications to enhance the anti-tumor efficacy of the PMMA cement, such as drug carriers and magnetic hyperthermia.

Graphical abstract: Comprehensive evaluation and advanced modification of polymethylmethacrylate cement in bone tumor treatment

Article information

Article type
Review Article
Submitted
01 Jul 2023
Accepted
28 Aug 2023
First published
04 Sep 2023
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2023,11, 9369-9385

Comprehensive evaluation and advanced modification of polymethylmethacrylate cement in bone tumor treatment

B. Chao, J. Jiao, L. Yang, Y. Wang, T. Yu, H. Liu, H. Zhang, M. Li, W. Wang, X. Cui, S. Du, Z. Wang and M. Wu, J. Mater. Chem. B, 2023, 11, 9369 DOI: 10.1039/D3TB01494K

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