Issue 43, 2023

Preparation and anti-tumor effects of mesoporous silica nanoparticles loaded with trifluoperazine

Abstract

We have developed a targeted nano-drug delivery system that effectively harnesses the anti-tumor properties of trifluoperazine (TFP), while concurrently mitigating its side effects on the central nervous system. The manufacturing process entailed the preparation of mesoporous silica nanoparticles (MSN-NH2), followed by the loading of trifluoperazine into the pores of MSN-NH2 and then surface modification with polyethylene glycol (PEG) and anisamide (AA), resulting in the formation of TFP@MSN@PEG-AA (abbreviated as TMPA) nanoparticles. In vitro and in vivo anti-tumor activity and hemolysis experiments showed that TMPA had an excellent safety profile and a good anti-tumor effect. Importantly, the drug content of the TMPA nanoparticle group was found to be significantly lower than that of the TFP group in the mouse brain tissue as determined by High Performance Liquid Chromatography (HPLC) detection. Therefore, the developed drug delivery system achieved the goal of maintaining TFP's anti-tumor action while avoiding its negative effects on the central nervous system.

Graphical abstract: Preparation and anti-tumor effects of mesoporous silica nanoparticles loaded with trifluoperazine

Article information

Article type
Paper
Submitted
29 Jun 2023
Accepted
13 Oct 2023
First published
14 Oct 2023

J. Mater. Chem. B, 2023,11, 10395-10403

Preparation and anti-tumor effects of mesoporous silica nanoparticles loaded with trifluoperazine

Y. Ma, L. Li, L. Mo, X. Wang, C. Liu, Y. Wu and C. Liu, J. Mater. Chem. B, 2023, 11, 10395 DOI: 10.1039/D3TB01472J

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