Issue 41, 2023

Cell or cell derivative-laden hydrogels for myocardial infarction therapy: from the perspective of cell types

Abstract

Myocardial infarction (MI) is a global cardiovascular disease with high mortality and morbidity. To treat acute MI, various therapeutic approaches have been developed, including cells, extracellular vesicles, and biomimetic nanoparticles. However, the clinical application of these therapies is limited due to low cell viability, inadequate targetability, and rapid elimination from cardiac sites. Injectable hydrogels, with their three-dimensional porous structure, can maintain the biomechanical stabilization of hearts and the transplantation activity of cells. However, they cannot regenerate cardiomyocytes or repair broken hearts. A better understanding of the collaborative relationship between hydrogel delivery systems and cell or cell-inspired therapy will facilitate advancing innovative therapeutic strategies against MI. Following that, from the perspective of cell types, MI progression and recent studies on using hydrogel to deliver cell or cell-derived preparations for MI treatment are discussed. Finally, current challenges and future prospects of cell or cell derivative-laden hydrogels for MI therapy are proposed.

Graphical abstract: Cell or cell derivative-laden hydrogels for myocardial infarction therapy: from the perspective of cell types

Article information

Article type
Review Article
Submitted
21 Jun 2023
Accepted
18 Sep 2023
First published
21 Sep 2023

J. Mater. Chem. B, 2023,11, 9867-9888

Cell or cell derivative-laden hydrogels for myocardial infarction therapy: from the perspective of cell types

Z. Xiong, Q. An, L. Chen, Y. Xiang, L. Li and Y. Zheng, J. Mater. Chem. B, 2023, 11, 9867 DOI: 10.1039/D3TB01411H

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