Issue 38, 2023

Cascade catalysis-coordinated nanorobots toward synergistic cancer chemoimmunotherapy

Abstract

Cancer has always been the biggest threat to human health, but the effect of traditional treatments such as surgery, chemotherapy, and radiotherapy is not satisfactory. Currently, nanomedicine-based chemoimmunotherapy can improve clinical results through unique synergistic effects. However, it is mainly enriched at tumor sites based on EPR effects, without an active delivery strategy and relatively low tumor targeting distribution. Therefore, nanorobots (Cu@MPS-GOD) with magnetic responsiveness and enzyme-like activity were prepared, which can enrich and move to the tumor site under the action of a 3D magnetic field, and cause tumor cell immunogenic death by cascade catalytic Fenton reactions. Meanwhile, Cu@MPS-GOD can also activate immune cells or induce cancer cells to expose surface antigens, trigger systemic anti-cancer immunity, and have a good inhibitory effect on a breast tumor model in mice with an inhibition rate of 59.3%. This work provides an attractive strategy to expand the therapeutic effect of cancer when chemical dynamic therapy is combined with immunotherapy, which has a potential clinical application prospect.

Graphical abstract: Cascade catalysis-coordinated nanorobots toward synergistic cancer chemoimmunotherapy

Supplementary files

Article information

Article type
Paper
Submitted
04 Jun 2023
Accepted
29 Aug 2023
First published
30 Aug 2023

J. Mater. Chem. B, 2023,11, 9201-9211

Cascade catalysis-coordinated nanorobots toward synergistic cancer chemoimmunotherapy

R. Guo, B. Wang, D. Liu, Y. Huang and Y. Lu, J. Mater. Chem. B, 2023, 11, 9201 DOI: 10.1039/D3TB01279D

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