Issue 20, 2023
From the journal:

Journal of Materials Chemistry B

A two-photon fluorescent probe for formaldehyde detection and regeneration in living cells†

Qi Song,a   Zhiqiang Liu, ORCID logo b   Jie Niu,b   Bowen Zheng,a   Jingcheng Hao ORCID logo a  and  Jie Jiang ORCID logo *ac  

* Corresponding authors

a Key Laboratory of the Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, China
E-mail: jiejiang@sdu.edu.cn

b State Key Laboratory of Crystal Materials, Shandong University, Jinan, Shandong 250100, P. R. China

c Shenzhen Research Institute of Shandong University, Shenzhen 518057, P. R. China

Abstract

A two-photon excited fluorescent probe CMB-1 has been rationally developed for the detection and regeneration of formaldehyde based on a novel nucleophilic addition of a secondary amine to FA and subsequential alcoholysis reactivity mechanism. It enables a specific turn-on response towards formaldehyde and facilitates the monitoring of exogenous and endogenous formaldehyde in living cells via both one- and two-photon microscopy, with minimal influence on its native homeostasis and local concentration.

Graphical abstract: A two-photon fluorescent probe for formaldehyde detection and regeneration in living cells

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Article information

DOI
https://doi.org/10.1039/D3TB00158J
Article type
Paper
Submitted
27 Jan 2023
Accepted
22 Apr 2023
First published
24 Apr 2023

J. Mater. Chem. B, 2023,11, 4408-4415

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A two-photon fluorescent probe for formaldehyde detection and regeneration in living cells

Q. Song, Z. Liu, J. Niu, B. Zheng, J. Hao and J. Jiang, J. Mater. Chem. B, 2023, 11, 4408 DOI: 10.1039/D3TB00158J

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