Issue 3, 2023

ROS-scavenging biomaterials for periodontitis

Abstract

Periodontitis is defined as a chronic inflammatory disease in which the continuous activation of oxidative stress surpasses the reactive oxygen species (ROS) scavenging capacity of the endogenous antioxidative defense system. Studies have demonstrated that ROS-scavenging biomaterials should be promising candidates for periodontitis therapy. To benefit the understanding and design of scavenging biomaterials for periodontitis, this review details the relationship between ROS and periodontitis, including direct and indirect damage, the application of ROS-scavenging biomaterials in periodontitis, including organic and inorganic ROS-scavenging biomaterials, and the various dosage forms of fabricated materials currently used for periodontal therapy. Finally, the current situation and further prospects of ROS-scavenging biomaterials in periodontal applications are summarized. Expecting that improved ROS-scavenging biomaterials could be better designed and developed for periodontal and even clinical application.

Graphical abstract: ROS-scavenging biomaterials for periodontitis

Supplementary files

Article information

Article type
Review Article
Submitted
25 Oct 2022
Accepted
18 Nov 2022
First published
21 Nov 2022

J. Mater. Chem. B, 2023,11, 482-499

ROS-scavenging biomaterials for periodontitis

E. Chen, T. Wang, Y. Tu, Z. Sun, Y. Ding, Z. Gu and S. Xiao, J. Mater. Chem. B, 2023, 11, 482 DOI: 10.1039/D2TB02319A

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