Issue 24, 2023

Palladium mono-N-protected amino acid complexes: experimental validation of the ligand cooperation model in C–H activation

Abstract

Mechanistic proposals for the C–H activation reaction enabled by mono-N-protected amino acid ligands (MPAAs) have been supported by DFT calculations. The direct experimental observation of the ligand-assisted C–H activation has not yet been reported due to the lack of well-defined isolated palladium complexes with MPAAs that can serve as models. In this work, palladium complexes bearing chelating MPAAs (NBu4)[Pd(κ2-N,O–AcN–CHR–COO)(C6F5)py] (Ac = MeC(O); R = H, Me) and [Pd(κ2-N,O–MeNH–CH2–COO)(C6F5)py] have been isolated and characterized. Their evolution in a solution containing toluene leads to the C–H activation of the arene and the formation of the C6F5–C6H4Me coupling products. This process takes place only for the ligands with an acyl protecting group, showing the cooperating role of this group in a complex with a chelating MPAA, therefore experimentally validating this working model. The carboxylate group is inefficient in this C–H activation.

Graphical abstract: Palladium mono-N-protected amino acid complexes: experimental validation of the ligand cooperation model in C–H activation

Supplementary files

Article information

Article type
Edge Article
Submitted
21 Apr 2023
Accepted
26 May 2023
First published
26 May 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2023,14, 6688-6694

Palladium mono-N-protected amino acid complexes: experimental validation of the ligand cooperation model in C–H activation

S. Fernández-Moyano, V. Salamanca and A. C. Albéniz, Chem. Sci., 2023, 14, 6688 DOI: 10.1039/D3SC02076B

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