Issue 14, 2023

Novel N(SCF3)(CF3)-amines: synthesis, scalability and stability

Abstract

We disclosed herein a straightforward strategy for the synthesis of unprecedented N-((trifluoromethyl)thio), N-(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the methodology has been demonstrated and the stability of the new motif has been studied.

Graphical abstract: Novel N(SCF3)(CF3)-amines: synthesis, scalability and stability

Supplementary files

Article information

Article type
Edge Article
Submitted
28 Nov 2022
Accepted
27 Feb 2023
First published
13 Mar 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2023,14, 3893-3898

Novel N(SCF3)(CF3)-amines: synthesis, scalability and stability

Y. Yang, N. Saffon-Merceron, J. C. Vantourout and A. Tlili, Chem. Sci., 2023, 14, 3893 DOI: 10.1039/D2SC06542H

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements